We make therapies happen - to help people age better, and live longer
Rejuveron is building a pipeline with breakthrough therapeutics along the hallmarks of aging
As cells age, their chromosomes become less stable and their DNA accumulates damage and mutation. DNA repair mechanisms also start to fail which leads to more mutations and promotes aging and disease.
Senescent cells are cells that should have died and been destroyed, as part of normal turnover, but instead stay alive and start making many proteins that negatively affect other cells in their surrounding (so called “zombie cells”), causing multiple associated diseases. As we age, we accumulate senescent cells, something we wish to prevent.
Telomere is the name given to the ends of each of our chromosomes, which are made of our DNA. As cells divide, telomeres get shorter until they become too short, causing our cells to age and stop functioning properly.
Deregulated Nutrient Sensing
High metabolic activity can put stress on our cells and cause them to age. However, when cells have limited nutrients available, they enter a regenerative mode, a state which has been shown to increase lifespan in mice. Mimicking this process with small molecules has the potential to increase health- and lifespan in humans too.
Mitochondria are the powerhouse of cells, as they use nutrients to make energy for us to live. However, with age, they build-up oxidative stress, mutations, and lose their integrity, which lead to cellular dysfunction and aging.
Stem Cell Exhaustion
With age, stem cells lose the ability to differentiate and replace cells throughout the body. This is particularly important in the bone marrow where stem cells give rise to blood and immune cells and where exhaustion of stem cells leads to a weak immune system, making the aged population particularly vulnerable to infection.
As cells are exposed to environmental factors, their DNA is subtly modified through epigenetic mechanisms. These changes accumulate over time, promoting alteration of gene expression which underlies several aging-related diseases.
Loss of Proteostasis
Our cells are constantly renewing proteins by degrading old proteins and making new ones. When these autophagic processes starts to fail, damaged and misfolded proteins accumulate in cells, leading to cellular death and aging.
Altered Intercellular Communication
As cells age, they show an increase in self-preserving signals as opposed to adequate chemical communication with their neighbors. For example, aged cells that become senescent will trigger chronic low-grade inflammation (so called-inflammaging) which contributes greatly to the aging process.
Discovering and developing endogenous regenerative medicines that repair tissues and organs
Identifying novel ways of targeting senescent cells to produce therapies that will improve health in old age.