Second Rejuveron company transitions into clinical stage as first patient is dosed in trial of Endogena Therapeutics’ novel regenerative treatment for blindness caused by retinitis pigmentosa

press release  ·  RJN-22-03

Schlieren, Zürich, Switzerland  ·  12 July 2022

Rejuveron Life Sciences AG (‘Rejuveron’), a Zürich-based biotechnology company developing therapies to promote healthy aging, is pleased to announce that the first participant has been treated in Endogena Therapeutics’ phase 1/2a clinical study of its lead product, EA-2353, a photoreceptor regeneration treatment for retinitis pigmentosa (RP).

See Endogena’s full press release here.

Rejuveron has a near-majority holding in Endogena, an endogenous regenerative therapeutics company, announcing in late 2021 that it had invested a further $20m in Endogena’s $29 million series A financing round, which has enabled it to progress treatments targeting degenerative diseases of the eye. 

This is the second program in the Rejuveron pipeline to enter clinical trials and follows the announcement in March that Rejuvenate BioMed, a Belgium-based biomedical company developing novel combination drugs for age-related diseases had commenced its first Phase 1 clinical trial assessing the company’s lead candidate RJx-01 for the treatment of sarcopenia. 

Endogena’s EA-2353 takes a novel, small-molecule approach and selectively activates endogenous retinal stem and progenitor cells, which differentiate into photoreceptors and can hence potentially preserve or restore visual function. This gene-independent treatment approach has significant advantages in RP, which has multiple genetic causes. EA-2353 has been granted orphan drug designation by the U.S. Food and Drug Administration in May 2021.

For more information on the clinical trials, please visit www.clinicaltrials.gov (Reference: NCT05392751).

About Rejuveron

Rejuveron is a clinical-stage biotechnology company creating therapies to improve healthy aging. Its experienced drug discovery and development team applies a deep understanding of the biology of aging, alongside technological advances in biopharmaceutical R&D, to progress a new generation of medicines that will help people to age better and live longer. 

Through its programs, each uniquely focused on preventing, repairing, or reversing the hallmarks of aging, Rejuveron is advancing a therapeutic pipeline that ranges from drug discovery to the clinic. Rejuveron’s business model is to create or acquire innovative programs, each being held within a wholly-owned or majority-owned company. 

Co-founded in 2019 by entrepreneurial scientist, Matthias Steger, and visionary investor, Christian Angermayer, Rejuveron has state-of-the-art incubator laboratory facilities and offices at its headquarters in Zürich’s Bio-Technopark (Switzerland), New York (USA), as well as program teams located in Spain and Belgium.

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About Endogena

Endogena Therapeutics Inc. is a clinical-stage biotech company that discovers and develops first-in-class endogenous regenerative medicines to repair and regenerate tissues and organs. Its approach has the potential to change the way degenerative conditions related to aging and genetic disorders are treated. The concept is based on selective regulation of endogenous adult stem- and progenitor cells for controlled tissue repair by small molecules. Endogena’s most advanced programs target degenerative diseases of the eye, including retinitis pigmentosa and geographic atrophy (secondary to AMD). Registered in San Francisco, USA, Endogena is part of the Rejuveron Life Sciences group of companies, with operations based in Rejuveron’s state-of-the-art laboratory facilities in Zürich’s Bio-Technopark and at JLABS in Toronto, Canada.

For more information, please visit www.endogena.com